[Serializable]
    public class NotificationAspect : OnMethodBoundaryAspect
    {
        private NotificationMethodType _type;
        private IUnitOfWork _uow;

        public NotificationAspect(NotificationMethodType type,IUnitOfWork uow )
        {
            _type = type; 
            _uow = uow;
        }
...

x.For<ISettingService>().Singleton().Use(() => new SettingService());

public SettingService(IUnitOfWork uow)
{
     _uow = uow;
}

app.MapHubs(new HubConfiguration { EnableCrossDomain = true });

PM> Install-Package Microsoft.Owin.Cors

app.UseCors(CorsOptions.AllowAll);