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Caching is a powerful tool in a programmer's toolbox but it isn't magic. It can help scale an application to a vast number of users or it can be the thing dragging down your application. Layered caching is a technique of stacking different types of cache on top of each other which play to different strengths. 

namespace DbConfig.Web.DomainClasses
{
    public class ConfigurationValue
    {
        public int Id { get; set; }
        public string Key { get; set; }
        public string Value { get; set; }
    }
}

    public class MyAppContext : DbContext, IUnitOfWork
    {
        public MyAppContext(DbContextOptions options) : base(options)
        { }

        public virtual DbSet<ConfigurationValue> Configurations { set; get; }

        protected override void OnModelCreating(ModelBuilder builder)
        {
            // it should be placed here, otherwise it will rewrite the following settings!
            base.OnModelCreating(builder);

            // Custom application mappings
            builder.Entity<ConfigurationValue>(entity =>
            {
                entity.Property(e => e.Key).HasMaxLength(450).IsRequired();
                entity.HasIndex(e => e.Key).IsUnique();
                entity.Property(e => e.Value).IsRequired();
                entity.HasData(new ConfigurationValue
                {
                    Id = 1,
                    Key = "key-1",
                    Value = "value_from_ef_1"
                });
                entity.HasData(new ConfigurationValue
                {
                    Id = 2,
                    Key = "key-2",
                    Value = "value_from_ef_2"
                });
            });
        }

    public class EFConfigurationSource : IConfigurationSource
    {
        private readonly IServiceProvider _serviceProvider;

        public EFConfigurationSource(IServiceProvider serviceProvider)
        {
            _serviceProvider = serviceProvider;
        }

        public IConfigurationProvider Build(IConfigurationBuilder builder)
        {
            return new EFConfigurationProvider(_serviceProvider);
        }
    }

    public class EFConfigurationProvider : ConfigurationProvider
    {
        private readonly IServiceProvider _serviceProvider;

        public EFConfigurationProvider(IServiceProvider serviceProvider)
        {
            _serviceProvider = serviceProvider;
            ensureDatabaseIsCreated();
        }

        public override void Load()
        {
            using (var scope = _serviceProvider.CreateScope())
            {
                var uow = scope.ServiceProvider.GetRequiredService<IUnitOfWork>();
                this.Data?.Clear();
                this.Data = uow.Set<ConfigurationValue>()
                               .AsNoTracking()
                               .ToList()
                               .ToDictionary(c => c.Key, c => c.Value);
            }
        }

        private void ensureDatabaseIsCreated()
        {
            using (var scope = _serviceProvider.CreateScope())
            {
                var uow = scope.ServiceProvider.GetRequiredService<IUnitOfWork>();
                uow.Migrate();
            }
        }
    }

    public static class EFExtensions
    {
        public static IConfigurationBuilder AddEFConfig(this IConfigurationBuilder builder,
            IServiceProvider serviceProvider)
        {
            return builder.Add(new EFConfigurationSource(serviceProvider));
        }
    }

namespace DbConfig.Web
{
    public class Startup
    {
        public void ConfigureServices(IServiceCollection services)
        {
            services.AddScoped<IUnitOfWork, MyAppContext>();
            services.AddScoped<IConfigurationValuesService, ConfigurationValuesService>();

            var connectionString = Configuration.GetConnectionString("SqlServerConnection")
                     .Replace("|DataDirectory|", Path.Combine(Directory.GetCurrentDirectory(), "wwwroot", "app_data"));
            services.AddDbContext<MyAppContext>(options =>
                    {
                        options.UseSqlServer(
                            connectionString,
                            dbOptions =>
                                {
                                    var minutes = (int)TimeSpan.FromMinutes(3).TotalSeconds;
                                    dbOptions.CommandTimeout(minutes);
                                    dbOptions.EnableRetryOnFailure();
                                });
                    });

            var serviceProvider = services.BuildServiceProvider();
            var configuration = new ConfigurationBuilder()
                                       .AddConfiguration(Configuration) // Adds all of the existing configurations
                                       .AddEFConfig(serviceProvider)
                                       .Build();
            services.AddSingleton<IConfigurationRoot>(sp => configuration); // Replace
            services.AddSingleton<IConfiguration>(sp => configuration); // Replace

namespace DbConfig.Web.Controllers
{
    public class HomeController : Controller
    {
        private readonly IConfiguration _configuration;

        public HomeController(IConfiguration configuration)
        {
            _configuration = configuration;
        }

        public IActionResult Index()
        {
            return Json(
                new
                {
                    key1 = _configuration["key-1"],
                    key2 = _configuration["key-2"]
                });
        }

    public class ConfigurationValuesService : IConfigurationValuesService
    {
        private readonly IConfiguration _configuration;

        public ConfigurationValuesService(IConfiguration configuration)
        {
            _configuration = configuration;
        }

        private void reloadEFConfigurationProvider()
        {
            ((IConfigurationRoot)_configuration).Reload();
        }

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Mousetrap is a standalone library with no external dependencies. It weighs in at around1.9kb minified and gzipped and 3.5kb minified.