var mockHttp = new MockHttpMessageHandler();

// Setup a respond for the user api (including a wildcard in the URL)
mockHttp.When("http://localhost/api/user/*")
        .Respond("application/json", "{'name' : 'Test McGee'}"); // Respond with JSON

// Inject the handler or client into your application code
var client = mockHttp.ToHttpClient();

var response = await client.GetAsync("http://localhost/api/user/1234");
// or without async: var response = client.GetAsync("http://localhost/api/user/1234").Result;

var json = await response.Content.ReadAsStringAsync();

// No network connection required
Console.Write(json); // {'name' : 'Test McGee'}